Cutting edge of mechanical imaging | Tsinghua team achieves new breakthrough in synchronous non-invasive measurement of multiple mechanical parameters of arteries!
PART01
New research, new progress
New Research & New Developments
Welcome to read the original text for more technical details and data support: https://doi.org/10.1126/sciadv.adv5660
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Continuous non-invasive estimation of blood pressure:The study found a significant correlation between the characteristics of circumferential guided waves and local blood pressure (Figure 2A-B). In experiments with different positions (such as neck extension), the sensitivity of circumferential waveguide velocity to posture is much lower than that of axial wave velocity, showing better robustness (Figure 2C). Compared with the percutaneous flattening method, this method has good comparability in the volunteer population (Figure 2D-E), and this research method does not require compression of blood vessels, significantly improving comfort and applicability.
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Synchronous inversion of stress and stiffness:By dynamically changing the wave properties such as the dispersion characteristics of axial and circumferential guided waves (Figure 3A, 3C, 3G), the bidirectional stress (Figure 3D-E, 3H-I) and stiffness (Figure 3F, 3J) of the vascular wall during diastole and systole can be inverted. Under the posture of neck extension, the axial stress significantly increases (about 13 kPa), while the circumferential stress changes less, highlighting the sensitivity and accuracy of this technique to changes in mechanical states (Figure 3D). The population data shows that the circumferential stress of the carotid artery is generally higher than the axial stress, and the circumferential stiffness is significantly greater than the axial stiffness, indicating that the mechanical properties of the arterial wall have strong anisotropy (Figure 3E – F, 3H – J).
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Measurement during cardiac cycle and pathological sensitivity:This study only requires about 4 milliseconds for a single data acquisition, supporting real-time tracking of changes in mechanical parameters within one or more cardiac cycles. The in vivo experimental results showed that there were significant differences in the mechanical characteristics of volunteers in the youth group, middle-aged and elderly normal blood pressure group, and middle-aged and elderly hypertension group, especially in the hypertension group where the circumferential stiffness and stress increased significantly, indicating the high sensitivity of this method in evaluating the vascular health status of this population (Figure 3G-J).
PART 02
Research Results Diagram
Research Findings Diagram
Figure 1: Schematic diagram of bidirectional guided wave excitation and measurement experiment and in vivo data
Figure 2: Comparison of blood pressure measurement results with flattening method shows excellent consistency
Figure 3: Characterization results of arterial stress and stiffness in various postures and populations
PART03
Conclusions and Prospects
Conclusion and Outlook
PART04
Collaboration Team and Author Introduction
Research Team & Author Introduction
About Xijian
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